Kanceri i gjirit i trash\u00ebguar (trash\u00ebguar ose familjar) \u00ebsht\u00eb i pranish\u00ebn tek 5-10% e t\u00eb gjith\u00eb pacient\u00ebve me kancer. T\u00eb dy gjenet BRCA1 dhe BRCA 2, jan\u00eb p\u00ebrgjegj\u00ebs p\u00ebr 80% t\u00eb kancerit t\u00eb gjirit t\u00eb trash\u00ebguar. Rreziku i shfaqjes s\u00eb kancerit tek grat\u00eb me mutacione BRCA1 deri n\u00eb mosh\u00ebn 70 vje\u00e7are, \u00ebsht\u00eb 85%, nd\u00ebrsa rreziku i kancerit ovarian (vezoreve) \u00ebsht\u00eb 45%. Rreziku i kancerit t\u00eb gjirit me mutacion gjenetik BRCA2, \u00ebsht\u00eb 84%, nd\u00ebrsa rreziku ndaj kancerit ovarian \u00ebsht\u00eb 76%.<\/p>\n

Si diagnostikohet?<\/span><\/p>\n

Diagnoza e BRCA1 dhe BRCA2 b\u00ebhet p\u00ebrmes testimit gjenetik. Pacient\u00ebt t\u00eb cil\u00ebt i p\u00ebrkasin k\u00ebtij grupi, k\u00ebshillohen t\u00eb kryejn\u00eb kontrolle t\u00eb gjirit duke filluar q\u00eb nga mosha 18 vje\u00e7are, mamografi nga mosha 25-35 vje\u00e7are dhe kontrolle t\u00eb rregullta t\u00eb gjirit \u00e7do 6 muaj ose \u00e7do vit si dhe rezonanc\u00eb magnetike t\u00eb gjirit nj\u00eb her\u00eb n\u00eb vit. \u00a0\u00cbsht\u00eb e r\u00ebnd\u00ebsishme q\u00eb t\u00eb mos i kap\u00ebrceni kontrollet n\u00eb lidhje me kancerin ovarian, \u00a0\u00e7do 6 muaj nga mosha 30-35 vje\u00e7are.<\/p>\n

Cilat jan\u00eb masat p\u00ebr kujdesin q\u00eb duhet t\u00eb merrni?<\/h2>\n

Nj\u00eb nga metodat kryesore p\u00ebr zvog\u00eblimin e rrezikut tek k\u00ebta pacient\u00eb, \u00ebsht\u00eb p\u00ebrdorimi i ila\u00e7eve t\u00eb cilat e mposhtin estrogjenin, si\u00e7 \u00ebsht\u00eb tamoksifeni ose raloksifeni ose intervenimet kirurgjike parandaluese t\u00eb cilat e zvog\u00eblojn\u00eb rrezikun. K\u00ebto intervenime kirurgjikale jan\u00eb p\u00ebrmendur si salpingo \u2013 oforektomia bilaterale dhe mastektomi profilaktike bilaterale. P\u00ebrdorimi i tamoksifenit ose raloksifenit, reduktojn\u00eb pjes\u00ebrisht kancerin e gjirit. Heqja e vezoreve tek k\u00ebta pacient\u00eb p\u00ebr q\u00ebllime parandaluese ul rrezikun e kancerit t\u00eb gjirit me 50%, nd\u00ebrkoh\u00eb q\u00eb\u00a0 mastektomia profilaktike mund ta zvog\u00ebloj\u00eb k\u00ebt\u00eb rrezik deri n\u00eb 90%.<\/p>\n

Kush duhet t\u00eb ket\u00eb konsultim gjenetik?<\/h2>\n

Konsultimet gjenetike jan\u00eb ve\u00e7an\u00ebrisht t\u00eb r\u00ebnd\u00ebsishme p\u00ebr grat\u00eb t\u00eb cilat n\u00eb rrethin e tyre t\u00eb ngusht\u00eb familjar\u00eb, kan\u00eb histori t\u00eb kancerit t\u00eb gjirit. Konsultuesit gjenetik i informojn\u00eb k\u00ebta pacient\u00eb n\u00ebse kan\u00eb nevoj\u00eb p\u00ebr teste gjenetike skrining p\u00ebr BRCA1 dhe BRCA2 dhe p\u00ebr avantazhet mjek\u00ebsore dhe psiko-sociale\u00a0 t\u00eb k\u00ebtyre testeve.<\/p>\n

Cil\u00ebt pacient\u00eb konsiderohen t\u00eb rrezikuar?<\/h2>\n

N\u00ebse keni nj\u00eb ose m\u00eb shum\u00eb an\u00ebtar\u00eb t\u00eb af\u00ebrt t\u00eb familjes apo m\u00eb t\u00eb larg\u00ebt, me kancer t\u00eb gjirit, ekziston mund\u00ebsia p\u00ebr t\u00eb patur kancer t\u00eb gjirit t\u00eb trash\u00ebguar. Kanceri i gjirit i cili \u00ebsht\u00eb i pranish\u00ebm n\u00eb mosh\u00eb t\u00eb re nga mosha 20-30 vje\u00e7are, s\u00eb bashku me kancerin ovarian, n\u00ebnkupton kancer t\u00eb gjirit t\u00eb trash\u00ebguar. Nj\u00eb faktor rreziku tep\u00ebr serioz \u00ebsht\u00eb n\u00ebse n\u00ebna apo motra juaj ka ose ka patur kancer t\u00eb gjirit.<\/p>\n","protected":false},"excerpt":{"rendered":"

Kanceri i gjirit i trash\u00ebguar (trash\u00ebguar ose familjar) \u00ebsht\u00eb i pranish\u00ebn tek 5-10% e t\u00eb gjith\u00eb pacient\u00ebve me kancer. T\u00eb dy gjenet BRCA1 dhe BRCA 2, jan\u00eb p\u00ebrgjegj\u00ebs p\u00ebr 80% t\u00eb kancerit t\u00eb gjirit t\u00eb trash\u00ebguar. Rreziku i shfaqjes s\u00eb kancerit tek grat\u00eb me mutacione BRCA1 deri n\u00eb mosh\u00ebn 70 vje\u00e7are, \u00ebsht\u00eb 85%, nd\u00ebrsa rreziku i kancerit ovarian (vezoreve) \u00ebsht\u00eb 45%. Rreziku i kancerit t\u00eb gjirit me mutacion gjenetik BRCA2, \u00ebsht\u00eb 84%, nd\u00ebrsa rreziku ndaj kancerit ovarian \u00ebsht\u00eb 76%.<\/p>\n","protected":false},"author":2,"featured_media":3449,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[367],"tags":[],"doktori":[],"class_list":["post-5710","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-kancer-sq"],"acf":[],"_links":{"self":[{"href":"https:\/\/healthacibadem.unet.mk\/wp-json\/wp\/v2\/posts\/5710","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/healthacibadem.unet.mk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/healthacibadem.unet.mk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/healthacibadem.unet.mk\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/healthacibadem.unet.mk\/wp-json\/wp\/v2\/comments?post=5710"}],"version-history":[{"count":0,"href":"https:\/\/healthacibadem.unet.mk\/wp-json\/wp\/v2\/posts\/5710\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/healthacibadem.unet.mk\/wp-json\/"}],"wp:attachment":[{"href":"https:\/\/healthacibadem.unet.mk\/wp-json\/wp\/v2\/media?parent=5710"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/healthacibadem.unet.mk\/wp-json\/wp\/v2\/categories?post=5710"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/healthacibadem.unet.mk\/wp-json\/wp\/v2\/tags?post=5710"},{"taxonomy":"doktori","embeddable":true,"href":"https:\/\/healthacibadem.unet.mk\/wp-json\/wp\/v2\/doktori?post=5710"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}